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The following information for US healthcare professionals include links to Sage-sponsored clinical trials that have been published in peer-reviewed journals as well as links to congress presentations on Sage compounds or brain health disorders. This information is provided as an educational resource for healthcare providers and should not be copied, modified, or disseminated.

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ZURZUVAE®

(zuranolone) capsules, for oral use, CIV

ZURZUVAE is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adults.

Download Full Prescribing Information including Boxed Warning
Download Medication Guide

Zuranolone is approved in the United States for the treatment of postpartum depression (PPD) in adults. Zuranolone is not approved for any other use. The safety and efficacy of zuranolone outside of the approved uses has not been established and there is no guarantee that investigational uses will be approved by a Health Authority.

As of January 1, 2025, ZULRESSO® (brexanolone) is no longer commercially available in the United States.

As of January 1, 2025, ZULRESSO® (brexanolone) is no longer commercially available in the United States.

SAGE-324 is an investigational compound. The efficacy and safety of SAGE-324 has not been established, and it has not been approved by any regulatory authority.

SAGE-718 is an investigational compound. The efficacy and safety of SAGE-718 has not been established, and it has not been approved by any regulatory authority.

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